ABSTRACT Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding capacity of the endoplasmic reticulum (ER) in proportion to the demand for virulence-related proteins that traffic through the secretory pathway. Although Ca2+ plays a pivotal role in ER function, the mechanism by which transcriptional upregulation of the protein folding machinery is coordinated with Ca2+ homeostasis is incompletely understood. In this study, we investigated the link between the UPR and genes encoding P-type Ca2+-ATPases in the human-pathogenic mold Aspergillus fumigatus. We demonstrate that acute ER stress increases transcription of the srcA gene, encoding a member of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA...
Accumulation of unfolded proteins within the lumen of the ER results in secretion stress in eukaryot...
SummaryIn eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected org...
Proteins destined to be secreted from eukaryotic cells are translocated to theendoplasmic reticulum ...
Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding ca...
International audienceThe filamentous fungal pathogen Aspergillus fumigatus secretes hydrolytic enzy...
The maintenance of endoplasmic reticulum (ER) homeostasis is critical for numerous aspects of cell p...
The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but...
We describe a new endoplasmic reticulum-associated stress response in the filamentous fungus Aspergi...
We describe a new endoplasmic reticulum (ER)-associated stress response in the filamentous fungus As...
<div><p>Proper protein folding in the endoplasmic reticulum (ER) is vital in all eukaryotes. When mi...
Proper protein folding in the endoplasmic reticulum (ER) is vital in all eukaryotes. When misfolded ...
ABSTRACT The unfolded protein response (UPR) is a signaling network that maintains homeostasis of th...
Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in respons...
The Aspergillus fumigatus pmrA (Golgi apparatus Ca2/Mn2 P-type ATPase) strain has osmotically suppr...
AbstractThe unfolded protein response (UPR) is a network of signaling pathways that responds to stre...
Accumulation of unfolded proteins within the lumen of the ER results in secretion stress in eukaryot...
SummaryIn eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected org...
Proteins destined to be secreted from eukaryotic cells are translocated to theendoplasmic reticulum ...
Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding ca...
International audienceThe filamentous fungal pathogen Aspergillus fumigatus secretes hydrolytic enzy...
The maintenance of endoplasmic reticulum (ER) homeostasis is critical for numerous aspects of cell p...
The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but...
We describe a new endoplasmic reticulum-associated stress response in the filamentous fungus Aspergi...
We describe a new endoplasmic reticulum (ER)-associated stress response in the filamentous fungus As...
<div><p>Proper protein folding in the endoplasmic reticulum (ER) is vital in all eukaryotes. When mi...
Proper protein folding in the endoplasmic reticulum (ER) is vital in all eukaryotes. When misfolded ...
ABSTRACT The unfolded protein response (UPR) is a signaling network that maintains homeostasis of th...
Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in respons...
The Aspergillus fumigatus pmrA (Golgi apparatus Ca2/Mn2 P-type ATPase) strain has osmotically suppr...
AbstractThe unfolded protein response (UPR) is a network of signaling pathways that responds to stre...
Accumulation of unfolded proteins within the lumen of the ER results in secretion stress in eukaryot...
SummaryIn eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected org...
Proteins destined to be secreted from eukaryotic cells are translocated to theendoplasmic reticulum ...